What makes the SkinMedica TNS Advanced+ Serum so effective for anti-aging?

The SkinMedica TNS Advanced+ Serum is powered by our next-generation, proprietary TNS® formula, which includes a unique blend of growth factors, peptides, and antioxidants. This advanced serum works synergistically to improve the appearance of coarse wrinkles, fine lines, and overall skin tone and texture. It's clinically proven to provide a more youthful appearance by supporting skin renewal and resilience.

How often should I use the SkinMedica TNS Advanced+ Serum for the best results?

For optimal results with the SkinMedica TNS Advanced+ Serum, apply one pump to your entire face, avoiding the eye area. Use it twice daily, in the morning and at night, after cleansing and before applying other treatment products or moisturizers. Consistent daily use is key to seeing improvements in your skin's texture and the appearance of fine lines and wrinkles.

I've heard about TNS, but what's the difference with the 'Advanced+' version?

The TNS Advanced+ Serum represents a significant leap forward from previous TNS formulas. It features a revolutionary blend of growth factors that goes beyond TNS-MR to include next-generation growth factors and brilliantly targeted peptides. This enhanced formula is designed to support skin renewal more effectively, address sagging skin, and lead to a visibly smoother, more radiant complexion. Many users notice a difference in skin texture and the appearance of lines more quickly with the Advanced+ formula.

SkinMedica TNS Advanced+ Serum, 30ml, Allure Best of Beauty Hall of Fame 4x Winner

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Hand holding SkinMedica TNS Advanced+ Serum, a growth factor skincare product for collagen and fine lines.

Woman applying SkinMedica TNS Advanced+ Serum for youthful, radiant skin—clinically proven anti-aging skincare.

Before and after skincare results showing improved skin texture and reduced wrinkles at week 2

Key skincare ingredients: TNS-MR & Renessensce (RSC) Advanced for age-defying, skin renewal, collagen support

Dual-pump skincare serum application guide for clean, dry skin with TNS Advanced+ Serum

SkinMedica TNS Advanced+ Serum new vs old packaging, same proven skincare formula

SkinMedica skincare products with reimagined packaging, featuring cleanser, serum, and sunscreen

New look, same formulas you love. SkinMedica skincare update announcement.

SkinMedica TNS Advanced+ Serum bottle and box, 30ml, luxury skincare product

SkinMedica TNS Advanced+ Serum bottle on a neutral stone surface with a plant leaf.

SkinMedica TNS Advanced+ Serum

Name: SkinMedica TNS Advanced+ Serum
SKU: 300236395100
Price: 295.0 USD
Availability: InStock

$295.00

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September Gift With Purchase: Receive a complimentary SkinMedica HA⁵ Hydra Collagen Replenish & Restore Hydrator ($192 value) with any SkinMedica purchase totaling $200 or more.

Offer valid September 1–30, 2026, while supplies last.

SkinMedica TNS Advanced+ Serum

SkinMedica TNS Advanced+ Serum is the only clinically proven growth factor serum to address sagging skin — the #1 concern among aging skin patients. Powered by the proprietary TNS-MR6 complex with over 110 growth factors, cytokines, and skin proteins, this next-generation formula visibly improves coarse wrinkles, skin tone, and texture with results measurable in as little as 2 weeks and continuing to improve through 24 weeks of daily use.

Award-winning and physician-trusted, TNS Advanced+ replaces the original TNS Essential Serum with an upgraded, fragrance-free formula that works for all skin types. Lightweight in feel, powerful in results — this is SkinMedica’s most advanced anti-aging serum to date.

Pairs beautifully with SkinMedica HA⁵ Rejuvenating Hydrator for a complete growth factor + hydration protocol.

Application

How to use

When to Apply Apply in the morning and evening after cleansing and toning.
Where to Apply Apply to your entire face (neck and chest if desired).
How to Apply Dispense on the back of your hand and blend together before applying to skin. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.

Ingredients

Aqua/Water/Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin

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Overall rating: 5.0 / 5 from 2 reviews.

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Other than expensive this is

"Other than expensive this is the best product I have used. Stopped for 1 month and I began to see a difference in my complexion. But back on it and within a month it was back to clear and smooth again. Love this!!🩷"

— Paula C. (5/5)