SkinMedica Retinol Complex 0.25 white serum bottle on a stone pedestal with sunlight shadows.

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SkinMedica Retinol Complex 0.25 white pump bottle with rose gold cap

Three SkinMedica Retinol Complex bottles with skincare benefit text on a light background.

Creamy skincare product swatch on beige background, highlighting PhytoShield Complex benefits.

Three silver bottles of retinol complex in different strengths for all skin types on a light background.

Before and after photos showing reduction in redness and fine lines after 12 weeks of skincare treatment.

Hand holding SkinMedica Retinol Complex 1.0 skincare serum bottle with usage instructions.

SkinMedica Retinol Complex 0.25%

Name: SkinMedica Retinol Complex 0.25%
SKU: 300234917014
Price: 64.0 USD
Availability: InStock

$64.00

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SkinMedica Retinol Complex 0.25%

The ideal starting point for retinol. SkinMedica Retinol Complex 0.25% renews skin and diminishes the appearance of fine lines while minimizing the irritation commonly associated with retinol use — thanks to the proprietary PhytoShield™ Complex, an antioxidant blend that enhances tolerability and skin texture simultaneously.

KEY BENEFITS

Renews skin and diminishes the appearance of fine lines and coarse wrinkles
Enhances skin tone, texture, and resiliency
PhytoShield™ Complex minimizes irritation while boosting antioxidant protection
Ideal entry-level concentration for retinol beginners or sensitive skin

WHO IT’S FOR

Those new to retinol, or anyone with sensitive skin looking to incorporate retinol into their routine for the first time. Starting at 0.25% allows the skin to acclimate before stepping up to a higher concentration.

RETINOL PROGRESSION

SkinMedica offers a complete retinol range — 0.25% (beginner) → 0.5% (intermediate) → 1.0% (advanced) — designed to help you gradually build retinol tolerance over time.

HOW TO USE

Apply a pea-sized amount to clean, dry skin in the evening. Begin with 2–3 times per week and gradually increase frequency as tolerated. Always follow with broad-spectrum SPF in the morning.

Application

How to use

When to Apply Apply In the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated.
Where to Apply Apply to entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
Caution Do not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use a daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.

Ingredients

Aqua/Water/Eau, Cetyl Ethylhexanoate, Glycine Soja (Soybean) Oil, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide NP, Bisabolol, Tocopheryl Acetate, Oryza Sativa (Rice) Bran Oil, Glycerin, Caprylic/Capric Triglyceride, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin