SkinMedica Retinol Complex 0.5 serum in a white pump bottle with a gold cap.

SkinMedica Retinol Complex 0.5 serum bottle and product packaging on a white background.

SkinMedica Retinol Complex skincare bottles with benefits for sun damage, fine lines, and renewal

Cream swatch on beige background with text highlighting PhytoShield Complex for retinol delivery

Before and after clinical study photos of a 56-year-old woman using Retinol Complex 0.5, showing visible skin improvement after 12 weeks.

Before and after images showing reduced wrinkles on a woman's eye area from retinol complex use.

Hand holding SkinMedica Retinol Complex 1.0 serum with usage instructions on a beige background.

Three SkinMedica Retinol Complex bottles in varying strengths with usage tips for all skin types.

Close-up of woman with clear skin and text promoting regenerative skincare innovation.

SkinMedica Retinol Complex 0.5%

Name: SkinMedica Retinol Complex 0.5%
SKU: 300234921011
Price: 80.0 USD
Availability: InStock

$80.00

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Offer valid September 1–30, 2026, while supplies last.

SkinMedica Retinol Complex 0.5%

The next step in the SkinMedica retinol progression. Retinol Complex 0.5% delivers enhanced renewal and visible anti-aging results for skin that has already been introduced to retinol — with the same PhytoShield™ Complex antioxidant blend to maintain tolerability and enhance skin texture while minimizing irritation.

KEY BENEFITS

Renews skin and diminishes the appearance of fine lines and coarse wrinkles
Enhances skin tone, texture, and resiliency
PhytoShield™ Complex minimizes irritation while boosting antioxidant protection
Appropriate step-up concentration for skin pre-conditioned to retinol

WHO IT’S FOR

Skin that has been pre-conditioned using Retinol Complex 0.25% or another retinoid product and is ready for a higher concentration.

RETINOL PROGRESSION

SkinMedica offers a complete retinol range — 0.25% (beginner) → 0.5% (intermediate) → 1.0% (advanced) — designed to help you gradually build retinol tolerance over time.

HOW TO USE

Apply a pea-sized amount to clean, dry skin in the evening. Begin with 2–3 times per week and gradually increase frequency as tolerated. Always follow with broad-spectrum SPF in the morning.

Application

How to use

When to ApplyApply In the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated.
Where to ApplyApply to entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
CautionDo not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use a daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.

Ingredients

Aqua/Water/Eau, Cetyl Ethylhexanoate, Glycine Soja (Soybean) Oil, Niacinamide, Polyacrylate-13, Caprylic/Capric Triglyceride, Glycerin, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide NP, Bisabolol, Tocopheryl Acetate, Oryza Sativa (Rice) Bran Oil, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin